A Structural Biologic Approach to Complex Wound Environments

Life Restoring Life

Chronic and complex wounds remain one of the most persistent challenges in healthcare. Despite advanced protocols, many wounds fail to progress predictably through the normal phases of healing, resulting in prolonged care, variability in outcomes, and increased burden on health systems. AyoVita™ was developed to bring greater consistency to this process: A structural, hydrated biologic platform designed to support tissue repair and help restore a more favorable healing environment.

The High Cost of Stalled Healing

Chronic wounds, such as pressure injuries and soft tissue defects, frequently stall in the early phases of repair. This lack of predictability doesn’t just delay recovery, it triggers a cycle of prolonged treatment, excessive resource utilization, and inconsistent patient outcomes

Progression is Key to Healing

Chronic wounds often fail to transition efficiently between these stages. AyoVita™ is designed to maintain structural support and protective coverage throughout the natural wound healing continuum. 

1.

Inflammatory Phase

2.

Proliferative Phase

3.

Remodeling Phase

A Structural Allograft Designed for the Wound Environment

AyoVita™ is a full-thickness, hydrated placental allograft regulated under 361 HCT/P and intended for homologous use to:

Suppletment, repair, or replace damaged or inadequate tissue.

By preserving native extracellular matrix architecture in a hydrated state, AyoVita™ maintains:

Native extracellular matrix components inherent to the tissue 

Native biologic components inherent to the tissue

This allows it to conform to irregular wound geometries while supporting

Protective Coverage & Tissue Preservation

Preservation Drives Potential

AyoVita™ is built on a simple principle: What is preserved determines what is possible.

Preserved Matrix Structure

By maintaining full-thickness structure in a hydrated state, the platform retains:

  • Collagen Architecture

    For structural continuity.

  • Elastin & Matrix Proteins

    For flexibility and physical support.

  • Proteoglycans & GAGs

    For hydration and matrix stability.

  • Native Extracellular Components

    Inherent to complex tissue structure

The Preserved Platform

This preserved structure and biologic payload contribute to:

  • A Protective Interface

    Formed directly over the wound bed.

  • Supportive Environment

    Optimized for cellular interaction

  • Organized Tissue Continuity

    Designed for protective coverage across multiple phases of wound management

A More Predictable Healing Environment

Preservation

Maintains native extracellular matrix structure in a hydrated state

Payload

Retains naturally occurring biologic components inherent to the tissue

Performance

Supports a more organized and balanced healing environment

Designed for Challenging Wounds

AyoVita™ adapts to real-world wound complexity while supporting tissue coverage and incorporation

Irregular wound margins

Conforms to complex wound shapes.

Complex Soft tissue defects

Structural support for tissue gaps.

Chronic, non-healing wounds

Restores the natural healing environment.

Pressure injures (Level 2-4)

Protects and hydrates deep tissue.

Post-Surgical Wound Environments

Reinforces and supports site stability.

Beyond Closure

The objective is not simply wound closure. It is how the tissue heals.
AyoVita™ is designed to support:

• Restoration of integument structure
• Organized tissue remodeling
• Progression toward epithelial coverage

Because durable outcomes depend on the quality of tissue regeneration, not just surface closure.

Chronic wound care is one of the most resource-intensive areas within healthcare systems.

From Reactive Care to Structured Healing

Earlier biologic intervention

More consistent progression through healing phases

Reduced variability in treatment pathways

Improved operational efficiency across wound programs

Hydration Preserves Biology

Many traditional approaches rely on dehydrated or minimally structured materials.

  • Hydrated preservation of tissue architecture

  • Full-thickness structural integrity

  • Retention of naturally occuring biologic components

This combination supports a more complete interaction with the wound environment.

Life Restoring Life

AyoVita™ reflects a belief that the most powerful solutions in medicine already exist within nature. Our role is not to out-engineer biology. It is to preserve it, and deliver it where it is needed most.

The New Standard in Wound Care

  • Native biologic payload

  • Supportive environment

  • A more consistent pathway toward healing

At Gratitude Theraputics, healing extends beyond the wound. Every AyoVita™ product represents:

A portion of every product supports individuals and communities seeking a fresh start.

Because growth and renewal are not only biological.

They are human.

A commitment to better patient outcomes

Advancing recovery standards through structural preservation and consistent biologic performance.

A step toward restoring structure and dignity

Supporting the physical and emotional journey toward total patient wellness.

An opportunity to create broader impact

Empowering communities by reinvesting in global health and human potential.

 

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A structural approach to wound care.
A platform designed for consistency.
A new standard for complex healing environments.